Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies
نویسندگان
چکیده
منابع مشابه
Wnt signaling mediates self-organization and axis formation in embryoid bodies.
Embryonic stem cells (ESCs) form descendants of all three germ layers when differentiated as aggregates, termed embryoid bodies. In vivo, differentiation of cells depends on signals and morphogen gradients that provide instructive and positional cues, but do such gradients exist in embryoid bodies? We report here the establishment of anteroposterior polarity and the formation of a primitive str...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2008
ISSN: 1934-5909
DOI: 10.1016/j.stem.2008.09.013